I don't see why not. Besides, how do you sample discriminately at such a place? The only way to know if they take care of their beer or not is to try it. I really don't see the difference in that regard with a place that has 5 taps.
Yeah, it's tougher to move enough beer on some of the lower-traffic taps to keep it fresh. But that's the case at every last bar in the world.
In other words, smaller is no guarantee of better, and some large-scale places do do a decent job of keeping things in good shape. Some do a lousy job. Some of the most awful, beat-up beer I've had has come from places with a number of taps I could count on one hand.
I don't understand what the neighborhood has to do with it. Each individual business is going to handle their beer differently, and you could have one place that serves pristine beer while the place across the street serves piss from kegs that have been sitting there for six months and is pushed through lines that haven't been cleaned in 12.
-Steve