I keep my beans in the freezer, which I believe is recommended, and
> grind each packet as and when needed.
>
> Is it best if I grind them direct from the freezer, leave them to
> defrost before grinding or doesn't it matter much?
If you're not re-freezing any, it doesn't matter. The only issue would have been of moisture condensed on the remaining beans (because of the cold) before being replaced in the freezer.