you got me all interested in this subject, not trying to "fight", but continue a discussion:
first of all, osteosarcoma i have yet to see something that had fluoride as etiology for osteosarcoma uptodate: the majority of osteosarcomas are sporadic (= no exact cause set), while inherited predisposition accounts for a minority of cases. Risk factors: Prior irradiation or chemotherapy Paget's disease and other benign bone lesions Inherited conditions - Genetic conditions : ...retinoblastoma, Li- Fraumeni syndrome, Rothmund-Thomson syndrome, and the related Bloom and Werner syndromes blah: bone tumors arise from an aberration of the normal process of bone growth and remodeling at a time when rapidly proliferating cells are particularly susceptible to oncogenic agents, mitotic errors, or other events leading to neoplastic transformation [18]. However, studies examining the relationship between factors related to growth and development and the risk of bone sarcomas have revealed no consistent pattern
- fluoride = loss of teeth, and jaw bone ??? never heard of that excess fluoride will do some damage in child's teeth impairing enamel formation or something, but loss of jaw bone!!!??? where do you find this????
3: do you have any published studies in big journals, not pubmed obscure research articles?
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62 articles only 2 have fluoride in the title and they concern acute poisoning in children.
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(1998) Moreover, primary mineralization defects, whether genetic (as in hypophosphatasia) or acquired (e.g., as a result of excess fluoride, aluminum, or bisphosphonate), are rare causes of rickets or osteomalacia.
nejm Volume 333:1495-1496 November 30, 1995 Number 22 Internationally, the agents used most widely for the treatment of postmenopausal osteoporosis are calcium, estrogen, calcitonin, fluoride, calcitriol, and an early bisphosphonate, etidronate. In general, these agents can be divided into two categories according to whether they stimulate bone formation or inhibit bone resorption. Fluoride, the only one of these agents that stimulates bone formation, can increase bone density substantially. The effect of fluoride on the risk of fractures has been disappointing, although reanalysis of the data from one large trial showed a protective effect in women who had moderate increases in bone density,3 and new, slow-release formulations offer promise.
nejm Preventing Glucocorticoid-Induced Osteoporosis 337:420, August 7,
1997 increases bone density. There is also some evidence of the effectiveness of calcitonin and fluoride in this context.