you got me all interested in this subject,
not trying to "fight", but continue a discussion:
first of all,
i have yet to see something that had fluoride as etiology for
the majority of osteosarcomas are sporadic (= no exact cause set),
while inherited predisposition accounts for a minority of cases.
Prior irradiation or chemotherapy
Paget's disease and other benign bone lesions
Inherited conditions - Genetic conditions : ...retinoblastoma, Li-
Fraumeni syndrome, Rothmund-Thomson syndrome, and the related Bloom
and Werner syndromes
blah: bone tumors arise from an aberration of the normal process of
bone growth and remodeling at a time when rapidly proliferating cells
are particularly susceptible to oncogenic agents, mitotic errors, or
other events leading to neoplastic transformation . However,
studies examining the relationship between factors related to growth
and development and the risk of bone sarcomas have revealed no
fluoride = loss of teeth, and jaw bone ???
never heard of that
excess fluoride will do some damage in child's teeth impairing enamel
formation or something,
loss of jaw bone!!!??? where do you find this????
do you have any published studies in big journals, not pubmed obscure
only 2 have fluoride in the title and they concern acute poisoning in
Moreover, primary mineralization defects, whether genetic (as in
hypophosphatasia) or acquired (e.g., as a result of excess fluoride,
aluminum, or bisphosphonate), are rare causes of rickets or
nejm Volume 333:1495-1496 November 30, 1995 Number 22
Internationally, the agents used most widely for the treatment of
postmenopausal osteoporosis are calcium, estrogen, calcitonin,
fluoride, calcitriol, and an early bisphosphonate, etidronate. In
general, these agents can be divided into two categories according to
whether they stimulate bone formation or inhibit bone resorption.
Fluoride, the only one of these agents that stimulates bone formation,
can increase bone density substantially. The effect of fluoride on the
risk of fractures has been disappointing, although reanalysis of the
data from one large trial showed a protective effect in women who had
moderate increases in bone density,3 and new, slow-release
formulations offer promise.
nejm Preventing Glucocorticoid-Induced Osteoporosis 337:420, August 7,
increases bone density. There is also some evidence of the
effectiveness of calcitonin and fluoride in this context.