NYT: More on the resveratrol story

hmmmm.....

so would non obese mice be healther if they drank wine or does it only help the obese?

No doubt. Some of the effects reported are both (i) dramatic and (ii) probably unexpected. For instance, the report showed a marked reduction in circulating insulin levels (especially in response to a food stimulus) and improved glucose tolerance, but no reduction in lipid markers, which would normally be considered an unlikely combination. [On the other hand, their data on fat distribution and body composition were minimal at best.] Leptin, which is normally a direct correlate of adiposity, was reduced versus the high-fat diet untreated group, but still way up compared to controls.

Also, not that the high-fat diet was *really* high-fat, with 60% of calories from fat - that's worse than even the average US diet, and will have contributed to the large impact on untreated subjects.

I'll avoid going off into endogeekspeak here :), but there are several details which suggest an improvement of the body's ability to accurately gauge fuel supply and maintain that sensing over time (as well as, not abnormally for a Nature report, several details skipped over... he says, jealously!)

If longevity is true with this process, who could afford to live that long?

It's fantastic news for growers of Pinot Noir (whose grapes have the highest known naturally-occurring concentration of resveratrol).

I'll drink to that.

Cheers,

David

Especially if you happen to be a wine-drinking rodent!

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